Compositions for the introduction of polyanionic m

专利名称：Compositions for the introduction of

polyanionic materials into cells

发明人：Steven Michial Ansell,Barbara Mui,Michael

Hope

申请号：US08/536584申请日：19950929公开号：US05785992A公开日：19980728

摘要：The present invention provides compositions and methods which are useful forthe introduction of polyanionic materials into cells. The compositions are mixtures ofcationic compounds and neutral lipids which are typically formulated as liposomes. Thecationic compounds are quaternary ammonium compounds wherein the nitrogen has twoattached long chain alkyl groups, at least one of which is unsaturated. The methods fortransfecting cells involve (a) contacting the polyanionic materials with the compositionsabove to form a polyanionic material-liposome complex, and (b) contacting the complexwith the cells to be transfected.

申请人：INEX PHARMACEUTICALS CORP.

代理机构：Townsend and Townsend and Crew LLP

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