Microbiological process for the production of arom

专利名称：Microbiological process for the production

of aromatic hydroxy- heterocyclic carboxylicacids

发明人：Andreas Kiener,Markus Rohner,Klaus

Heinzmann

申请号：US08/384695申请日：19950203公开号：US05516661A公开日：19960514

摘要：The microbiological process for the production of hydroxy- heterocycliccarboxylic acid of formula ##STR1## wherein R.sub.1 means a hydrogen or a halogenatom and X means a nitrogen atom or a CR.sub.2 function, wherein R.sub.2 means ahydrogen or halogen atom, starting from the corresponding heterocyclic carboxylic acid.The process is performed so that an aerobic biomass which utilizes nicotinic acid, iscultivated in a molar ratio of nicotinic acid to mineral acid of 1 to 8. The ratio is assuredover the entire cultivation phase. The the hydroxylation of the corresponding

heterocyclic carboxylic acid of the general formula ##STR2## wherein R. sub.1 and X havethe above-mentioned meanings, is performed with the biomass. Under these conditions,strain Pseudomonas acidovorans DSM 7205, strain Pseudomonas acidovorans DSM 7203,strain Alcaligenes faecalis DSM 7204 and strain Arthrobacter crystallopoietes DSM 7202are concentrated in the cultivation phase.

申请人：LONZA LTD.

代理机构：Fisher, Christen & Sabol

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