专利名称：MULTIPLEX RNA-GUIDED GENOME
ENGINEERING
发明人：CHURCH, George, M.,DICARLO, James申请号：EP14822995.8申请日：20140708公开号：EP3019616A1公开日：20160518
摘要：Methods of multiplex genome engineering in cells using Cas9 is provided whichincludes a cycle of steps of introducing into the cell a first foreign nucleic acid encodingone or more RNAs complementary to the target DNA and which guide the enzyme to thetarget DNA, wherein the one or more RNAs and the enzyme are members of a co-localization complex for the target DNA, and introducing into the cell a second foreignnucleic acid encoding one or more donor nucleic acid sequences, and wherein the cycle isrepeated a desired number of times to multiplex DNA engineering in cells.
申请人：President and Fellows of Harvard College
地址：17 Quincy Street Cambridge, MA 02138 US
国籍：US
代理机构：Tombling, Adrian George
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