COPOLYMER INCLUDING UNCHARGED HYDROPHILIC BLOCK AN

专利名称：COPOLYMER INCLUDING UNCHARGED

HYDROPHILIC BLOCK AND CATIONICPOLYAMINO ACID BLOCK HAVING LATERALCHAIN TO WHICH HYDROPHOBIC RADICALIS PARTIALLY INTRODUCED, AND USE OFCOPOLYMER

发明人：KATAOKA, Kazunori,NISHIYAMA,

Nobuhiro,ISHII, Atsushi,KATO,Yasuki,MIYATA, Kanjiiro,KIM,Hyunjin,TAKEMOTO, Hiroyasu

申请号：EP09720268.3申请日：20090306公开号：EP2272897A1公开日：20110112

专利附图：

摘要：The present invention relates to a block copolymer containing an unchargedhydrophilic polymer chain block and a cationic polyamino acid chain block, wherein thehydrophilic polymer chain block is covalently bound to one end of the main chain of thepolyamino acid chain block, and the hydrophobic group is covalently bound to the sidechains of not less than 10% and not greater than 70% of amino acid repeating units in thepolyamino acid chain block. This block copolymer forms a stable aggregate with siRNA, asmall-molecule nucleic acid, under a physiological condition.

申请人：The University of Tokyo

地址：3-1, Hongo 7-chome Bunkyo-Ku Tokyo 113-8654 JP

国籍：JP

代理机构：Dean, John Paul

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