专利名称：IDENTIFICATION OF SPECIFIC
APOLIPOPROTEIN EPITOPES ON
CIRCULATING ATHEROGENIC LOW-DENSITYLIPOPROTEIN
发明人：Chu-Huang Chen,Liang-Yin Ke申请号：US14343529申请日：20120910
公开号：US20150148410A1公开日：20150528
摘要：An isolated peptidic fragment of apolipoprotein E comprises at least 3contiguous amino acids, Including glycosylated threonine 194, threonine 289, serine 94,or serine 76 of SEQ ID NO.: 1, or any combination of those. An antibody capable ofbinding to the isolated peptidic fragment. A method of detecting a naturally-occurringcirculating atherogenic low-density lipoprotein in a plasma sample from an individual,comprising qualitatively and/or quantitatively detecting in a low-density lipoprotein thatbinds to the antibody. A method of assessing an individual's risk of ischemic heart diseaseand/or atherosclerosis comprises quantifying in a plasma sample from the individual anamount of apolipoprotein E comprising glycosylated threonine 194, threonine 289, serine94 or serine 76 of SEQ ID NO.: 1, or any combination of those.
申请人：Texas Heart Institute
地址：Houston TX US
国籍：US
更多信息请下载全文后查看
因篇幅问题不能全部显示，请点此查看更多更全内容