专利名称:Porphenins--antibiotic peptides
发明人:Vladimir N. Kokryakov,Sylvia S Harwig,Robert
I. Lehrer
申请号:US08/477131申请日:19950607公开号:US05889152A公开日:19990330
摘要:Peptide-based compounds containing multiple proline residues are useful aspreservatives and in preventing, treating, or ameliorating microbial infection, especiallyGram-negative bacterial infection in animals and plants, in treating conditions
characterized by the presence of LPS. These compounds are of the formula ##STR1##including the N- terminal acylated and/or C-terminal amidated or esterified formsthereof
wherein each of A.sub.1, A.sub.5, A.sub.10, A. sub.14 and A. sub.20 is independently Ala,Gly or Ser;
each of A.sub.2, A.sub.4, A.sub.7, A.sub.9, A.sub.11, A.sub.12, A.sub.13, A.sub.16,
A.sub.17, A. sub.19 and A.sub.22 is independently a hydrophobic amino acid selected fromthe group consisting of Ile, Leu, Val, Phe and Met;
each of A. sub.3 and A.sub.8 is independently a neutral polar amino acid selected fromAsn and Gln or is a hydrophobic amino acid selected from the group consisting of Ile, Leu,Val, Phe and Met;
each of A.sub.6, A.sub.18 and A.sub.21 is independently a basic amino acid selected
from Arg, Lys, and Har; and< P>
wherein A.sub.15 is Trp or a basic amino acid selected from Lys, Arg and Har;
wherein n is an integer of 1-6; and< P>
the antimicrobial or LPS-binding fragments thereof. Recombinant materials for theproduction of these peptides are also disclosed.
申请人:REGENTS OF THE UNIVERSITY OF CALIFORNIA
代理机构:Morrison & Foerster
更多信息请下载全文后查看
因篇幅问题不能全部显示,请点此查看更多更全内容