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METHOD FOR PRODUCING DISINTEGRATING PARTICULATE CO

2022-11-29 来源:好走旅游网
专利内容由知识产权出版社提供

专利名称:METHOD FOR PRODUCING

DISINTEGRATING PARTICULATE

COMPOSITION COMPRISING ACID-TYPECARBOXYMETHYLCELLULOSE,DISINTEGRATING PARTICULATE

COMPOSITION COMPRISING ACID-TYPECARBOXYMETHYLCELLULOSE, AND ORALLYDISINTEGRATING TABLET INCLUDINGDISINTEGRATING PARTICULATE

COMPOSITION COMPRISING ACID-TYPECARBOXYMETHYLCELLULOSE

发明人:HIRAMURA, Takahiro,IKURA,

Kiyoshi,ISHIKAWA, Sae,OKABAYASHI,Tomohito,HASHIKAWA, Naohiro,MORITA,Tetsuro,IKEDA, Kimiko,WAKAYAMA, Haruka

申请号:EP13767870.2申请日:20130327公开号:EP2832350A1公开日:20150204

摘要:An object of the present application is to provide an orally-disintegrating tablethaving excellent tablet hardness and disintegrability and a disintegrative particulatecomposition by which the orally-disintegrating tablet can be obtained with a relativelylow tablet compression force and which can provide excellent moldability, as well as a

method of producing the same, etc. The present application relates to a method ofproducing a disintegrative particulate composition including three components consistingof a first disintegrator component of an acid-type carboxymethylcellulose, a seconddisintegrator component and an excipient, the method including a first wet granulationstep using any two of the three components, and a second wet granulation step usinggranules obtained in the first wet granulation step and the remaining one component ofthe three components not used in the first wet granulation step; a production methodfurther including a crystalline cellulose as a fourth component; a production methodincluding a third step of mixing a crystalline cellulose into granules obtained in thesecond wet granulation step; disintegrative particulate compositions obtained by thesemethods, etc.

申请人:Daicel Corporation,Nichirin Chemical Industries, Ltd.

地址:Mainichi Intecio 3-4-5, Umeda, Kita-ku Osaka-shi, Osaka 530-0001 JP,320 Senzo4-chome Itami-shi, Hyogo 664-0898 JP

国籍:JP,JP

代理机构:Power, David

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